Principal Investigator

MR_HR_1c1 Milica Radisic  Professor, Institute of Biomaterials and Biomedical Engineering,Department of Chemical Engineering and Applied Chemistry

 

 CONTACT INFORMATION

       Name:  Milica Radisic
       Mailing Address: 164 College Street, Room 407 Toronto, ON    M5S 3G9    CANADA
       Office: 170 College Street Mining Building, Room 317 (416) 946-5295
       Laboratory: 170 College Street Lassonde Mining Building, Room 301 (416)-946-5322
       Fax: Dept.  (416) 978-4317
       Email: m.radisic@utoronto.ca
       Web Page: http://chem-eng.utoronto.ca/~milica/

 

EDUCATION

Post Doctorate Harvard-MIT Division of Health Science and Technology

Massachusetts Institute of Technology                                                                                                    2004-2005

Advisor: Gordana Vunjak-Novakovic

Ph.D.  Chemical Engineering, Massachusetts Institute of Technology                                           1999-2004

Doctoral thesis: “Biomimetic Approach to cardiac Tissue Engineering”

Advisor: Robert Langer

B.Eng. Chemical Engineering, McMaster University                                                                        1996-1999

Undergraduate thesis: “Interfacial tension in polymer melts”

Advisor: Andrew Hrymak

Chemical Engineering, University of Novi Sad, Serbia                                                                      1995-1996

 

 AFFILIATIONS

  • 01/2011-current:  Member of  Ontario Stem Cell Initiative (OSCI)
  • 07/2007- current: Affiliated Scientist, Toronto General Hospital Research Institute (TGRI)
  • 09/2006 –current: Member Heart & Stroke/Richard Lewar Center of Excellence in Cardiovascular Research (HSRLCE), University of Toronto
  • 07/2005-06/2009: Principal Investigator, Advanced Regenerative Tissue Engineering Centre (ARTEC)
    University of Toronto, Sunnybrook & Women’s Hospital Health Sciences Center, Toronto
  • 07/2005-current: Associate Member, Pediatric Regenerative Medicine Program (PRM)
    Hospital for Sick Children, Toronto
  • 07/2005-current: Research Collaborator Tissue Engineering Resource Center (TERC)
    Tufts University, MIT, NIH

 

PROFESSIONAL REGISTRATIONS

2011-current  P.Eng. License, Professional Engineers Ontario

2007-2011 Engineering Intern Training (EIT), Professional Engineers Ontario

 

AWARDS

02/2014 E.W.R. Steacie Memorial Fellowship, National Science and Engineering Research Council of Canada

05/2013 University of Toronto Inventor of the Year Award (with Axel Guenther, Liang Leng, Arianna McAllister, Andrew Woollard and Boyang Zhang)

02/2013 Queen Elizabeth II Diamond Jubilee Medal

07/2012 McLean Award, University of Toronto

06/2012 Engineers Canada Young Engineer Award

11/2011 Canada Research Chair Functional Cardiovascular Tissue Engineering (Tier 2)

07/2011 Young Engineer Award; Professional Engineers Ontario

01/2011 Connaught Innovation Award; University of Toronto

06/2010 Scientist to Watch; named by the Scientist Magazine

06/2010 McMaster Arch Award for work in Bioengineering, McMaster University Alumni Association, Recognizes McMaster’s graduates within 10 years after convocation for their unique and interesting contributions to society, their local community, and to McMaster University.

04/2010 NSERC Discovery Accelerator Supplement

01/2010 2010’s People to Watch; Toronto Star

04/2009 Breaking the Glass Ceiling Award; Women in Science and Engineering Club, University of Toronto

08/2008 MIT Technology Review Top 35 Innovators under 35 (TR35)

08/2007 Early Researcher Award; Ministry of Research and Innovation, Ontario

07/2003 Cambridge Science Foundation Travel Grant

05/ 2002 Poitras Pre-Doctoral Fellowship; awarded for studies in biomedical engineering, MIT 

06/2000-06/2004 Studenica Foundation Graduate Fellowship

06/1999 The Canadian Society of Chemical Industries Merit Award; awarded to Chemical Engineering graduand with the highest cumulative average

04/1999 The Presidential Graduate Fellowship; awarded by the Department of Chemical Engineering, Massachusetts Institute of Technology for exceptional record and promising future

11/1998 The Chancellor’s Gold Medal; the highest University award for undergraduate students, awarded for academic excellence, leadership and influence, McMaster University

09/1998 The Herbert A. Ricker Scholarship; awarded for academic excellence, McMaster University

02/1998 CSChE Student Paper Award (2nd Place)  “The role of defoamers in brownstock washing”

11/1997 The Mabel Stoakely Scholarship; awarded for outstanding academic achievement and leadership, McMaster University

10/1997 ICI Canada Inc. Scholarship for outstanding performance in Level Two Chemical Engineering, McMaster University

 

INVITED PRESENTATIONS

  1. “Engineering microenvironments for cardiovascular regeneration “, 4th International conference on Stem Cell Engineering (ICSCE) organized by SBE and ISSCR, Coronado, CA, March 16-17, 2014
  2. “Engineering microenvironments for cardiovascular regeneration”,  Excellence in Interventional Cardiology 2013, Whistler, BC, December 6th, 2013
  3. “Healthy and diseased heart tissue on a chip”, University of Pennsylvania Bioengineering’s 40th Anniversary Symposium, Philadelphia, PA, November 21st, 2013
  4. “Engineering microenvironments for cardiovascular regeneration”, Faculty of Applied Science and Engineering, Harvard University, April 15th, 2013
  5. “Engineering microenvironments for cardiac applications”, Gladstone Institute of Cardiovascular Disease, San Francisco, CA, October 14th, 2013
  6. “Tissue engineering for cardiac applications”, International Summer School, Piran/Vipava, Slovenia,  August 28th, 2013
  7. “3D Cell Culture and Bioreactors”, International Summer School, Piran/Vipava, Slovenia,  August 26th, 2013
  8. “Engineering microenvironments for cardiovascular regeneration”,  Emory University/Georgia Institute of Technology, July 17th, 2013
  9. “Biological Wire: A New Platform for Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes”, MFI Symposium, Ottawa Heart Institute, Ottawa, ON, June 28th, 2013
  10. “Healthy and diseased heart tissue on a chip”, Beyond Borders: Lyon Sachs Symposium,
  11. Technion, Haifa, IL May 08th, 2013
  12. “Novel Approach to Engineered Microvascular Networks”, Conference on Cell Therapy for Cardiovascular Disease, New York, NY, Jan 24th, 2013
  13. “Tissue Engineering”, Health Canada, Ottawa, ON, November 30th, 2012
  14. “Bioreactors for Development of Healthy and Diseased Myocardial Tissue Models”,  NIH Tissue Engineering Resource Center Site Visit, Tufts University, Boston, MA,  November 08, 2012
  15. “Healthy and Diseased Heart Tissue on a Chip”, IBBME Seimnar Series, University of Toronto, Sept 27th, 2012
  16. “Bioreactors for Development of Healthy and Diseased Myocardial Tissue Models”, TERMIS World Congress, Vienna, Austria, September 08th, 2012
  17. “Engineering Microenvironments for Cardiovascular Regeneration”  NSERC CREATE-IDEM, McMaster University, Hamilton, ON, July 10th, 2012
  18. “Healthy and Diseased Heart Tissue on a Chip”, Alumni Spring Reunion Engineering Lectures, University of Toronto, June 02nd, 2012
  19. “Healthy and Diseased Heart Tissue on a Chip”, Functional Imaging in Regenerative Medicine, NIST, Gaithersrburg, MD, May 31st, 2012
  20. “Engineering Microenvironments for Cardiovascular Regeneration” TMF, University of Belgrade, June 29th, 2012
  21. “Engineering microenvironments for cardiovascular regeneration”, Department of Bioengineering, University of California-San Diego, April 19, 2012
  22. “In vitro models of heart disease and regeneration” Experimental Biology 2012, America Association of Anatomists, April 25th, 2012 Sand Diego, CA
  23. “Engineering microenvironments for cardiovascular regeneration”, Department of Chemistry, York University, April 19, 2012
  24. “Controlled delivery of Thymosin β4 for tissue engineering and cardiac regenerative medicine”, Third International Symposium on Thymosins in Health and Disease,   March 15, 2012, Washington, DC
  25. “Healthy and Diseased Heart Tissue on a Chip”, Chemical Engineering Research Consultants Limited,  March 09, 2012, Toronto, ON
  26. “Healthy and Diseased Heart Tissue on a Chip”, CCRM-Roche Meeting, March 12, 2012, Toronto, ON
  27. “Collagen patches for cardiac repair”, California Institute for Regenerative Medicine Tissue Engineering Workshop (closed, by invitation), Jan 11-14, 2012 San Francisco, CA
  28. “Tissue Engineering and Biomaterials for Cardiovascular Regeneration”, Personalized Medicine in the Genomics Era, Oct 17th, 2011 Toronto, ON
  29. Discussant for “A Phase II Dose-Escalation Study of Allogeneic Mesenchymal Precursor Cells in Patients With Ischemic and Nonischemic Heart Failure”  by Perin et al American Heart Association Scientific Sessions, Nov 14, 2011 Orlando, Florida
  30. “Engineering Microenvironments for Cardiovascular Regeneration”, Biochemical and molecular engineering XVII, June 26-30, 2011 Seattle, WA
  31. “Healthy and diseased heart tissue on a chip”, School of Engineering and Applied Sciences, Harvard University, Boston, MA, April 27th, 2011
  32. “Engineering Microenvironments for Cardiovascular Regeneration”,  Tokyo Women’s Medical University, Tokyo, Japan, March 03, 2011
  33. “Engineering Microenvironments for Cardiovascular Regeneration”, 10th Congress of the Japanese Society for Regenerative Medicine, Tokyo, Japan, March 01, 2011
  34. “Engineered Heart Tissue” presentation to External Reviewers of the Department of Chemical Engineering and Applied Chemistry, Dec 02, 2010
  35. “Engineered Heart Tissue”, 2010 AHA Scientific Sessions, November 15, Chicago, IL
  36. Student Meet the Mentor Lunch, 2010 TERMIS-NA Meeting, Orlando, FL
  37. “Cardiac tissue engineering”, Laurence Becker Symposium on Advances in Laboratory Medicine- Frontiers in Tissue Engineering: Paediatric Regenerative Medicine, The Hospital for Sick Children, Toronto, June 03, 2010
  38. “Innovation in Tissue Engineering and Regenerative Medicine”, The International Diaspora Youth Leadership Conference, March 22, 2010, Toronto, ON
  39. “Engineered Heart Tissue for Drug Development” Presentation to Merrimack Pharma on Feb 12, 2009
  40. “Engineering Microenvironments for Cardiovascular Regeneration” Symposium on Advanced Research, Jan 12, 2010
  41. “Women in Research and Teaching” National Conference on Women in Engineering 2009: Designing the World to Come, Toronto, Nov 28, 2009
  42. “Immobilized Growth Factors for Vascularization of Engineered Tissues” Symposium in Honor of Dr. Michael Sefton’s 60th Birthday, University of Toronto, October 16, 2009
  43. “From Cells to Tissue Engineering: Re-making of the Heart” Institute of Medical Science Summer Program, University of Toronto, June 24, 2009
  44. “Tissue Engineering” REMEDI Symposium, Toronto General Research Institute, June 12, 2009
  45. “Biomaterials and Bioreactors for Stem Cell Differentiation” Toronto Stem Cell Rounds, Toronto, ON May 04, 2009
  46. “Cardiac Tissue Engineering”, The Royal Canadian Institute (RCI) for the Advancement of
  47. Science, Table Host for “The RCI Science Dinner of the Year”, April 23, 2009
  48. “Cardiac Tissue Engineering”, Design of Medical Devices Conference, April 14-16, 2009 Minneapolis, MN
  49. “Tissue Engineering of a Living Cardiac Patch”, VIPSI2009 and World Rector Conference, April 02-04 2009, Belgrade, Serbia
  50. Panel on Regenerative Medicine, 2008 Emerging Technologies Conference, M.I.T., Cambridge, MA (declined due to maternity leave)
  51. Panel of Women in Technology, 2008 Emerging Technologies Conference, M.I.T., Cambridge, MA (declined due to maternity leave)
  52. Discussion Leader, “Engineering Cell Responses to ECM”, Gordon Research Conference Signal Transduction By Engineered Extracellular Matrices, July 6-11, 2008, Bates College
  53. Lewiston, ME
  54. “Engineering Microenvironments for Cardiovascular Regeneration” Department of Chemical and Biological Engineering, SUNY at Buffalo, Buffalo, NY, March 19, 2008
  55. “Ex-vivo construction of myocardial tissue: Bioreactor Cultivation” The 4th International Conference on Cell Therapy for Cardiovascular Diseases, New York, NY, Jan 17, 2008
  56. “Microfluidic Enrichment of Heart Cell Subpopulations” Ontario-on-a-Chip, University of Toronto, Nov 01, 2007
  57. “Engineering Microenvironments for Cardiovascular Regeneration” Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, May 10, 2007
  58. “Size and Adhesion Based Microfluidic Enrichment of Cardiac Cell Populations” 90th Canadian Chemistry Conference and Exhibition (CSC), Winnipeg, MB, May 27, 2007
  59. “Micro-scale systems in cardiac tissue engineering” National research Council (NRC), Industrial Materials Institute (IMI), Boucherville, QC, Canada (Laboratory of Dr. T. Veres), Sept 28, 2006
  60. “Biomimetic Approach to Cardiac Tissue Engineering” Annual Cardiovascular Scientific Day, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto May 11, 2006
  61. “Biomimetic Approach to Cardiac Tissue Engineering” ARTEC Technology Exchange, Jan 25, 2006, Toronto, ON
  62. “My experience as an assistant professor” THE500 (Dr. Kay, instructor), University of Toronto, guest lecture, March 21, 2006
  63. “Biomimetic Approach to cardiac Tissue Engineering” Toronto General Hospital (Laboratory of Dr. R-K. Li ) Dec 09, 2005
  64. “Biomimetic Approach to cardiac Tissue Engineering” Department of Pharmacology, SUNY Upstate Medical University,  Dec 01, 2005
  65. “Biomimetic requirements for cardiac tissue engineering” Tissue Engineering the Next Generation, NIH Sponsored Workshop May 02-04 2005, Cambridge, MA
  66. “ Biomimetic Approach to Cardiac Tissue Engineering” McMaster University, Feb 16, 2004

 

PROFESSIONAL ASSOCIATION MEMBERSHIPS

  • (2012-current) American Associate for the Advancement of Science (AAAS)
  • (2010-current) Biomedical  Engineering Society (BMES)
  • (2006-2007) American Society for Engineering Education (ASEE)
  • (2005-current) Society for Biological Engineering (SBE)
  • (2005-current) American Institute of Chemical Engineers (AIChE), Senior Member since 2008
  • (2003-2006, 2010) Materials Research Society (MRS)
  • (2003-current) Tissue Engineering and Regenerative Medicine Society International (TERMIS)

 

PROFESSIONAL ASSOCIATION ACTIVITIES

  • 2014 TERMIS-AM Annual Meeting, Dec 11-15, Washington, DC; Scientific Advisory Committee Member
  • 2013-ongoing, Contributing member of Faculty of 1000 (F1000)
  • 2013 Founding chair of the Cardiovascular/Angiogenesis/Blood Thematic Working Interest Group (TWIG) at TERMIS-AM
  • 2013 BMES Annual Meeting, Sept 25-28,  Seattle WA; Cardiovascular Engineering Track Chair; Abstract Reviewer
  • 2013-2014 TERMIS-AM Membership Committee Chair
  • 2013 TREMIS-AM Annual Meeting, November 10-13, Atlanta, GA; Organizer of the Inaugural  Workshop onWomen in Tissue Engineering and Regenerative Medicine. Wrote proposals to fund the Workshop.
  • 2013 TREMIS-AM Annual Meeting, November 10-13, Atlanta, GA; Session Co-Chair: Engineering Tissues for in vitro Screening and Diagnostics
  • 2013 Society for Biomaterials Annual Meeting, April 10-13, Boston, MA; Session co-Chair: Biomaterials for Cardiac Repair
  • 2013 Symposium Organizer “Beyond Borders: Lyon Sachs Symposium on Tissue Engineering and Regenerative Medicine”, Haifa, IL, May 06-08
  • 2012-current, Member of Ontario Society of Professional Engineers Women in Engineering Committee
  • 2012 IBBME 50th Anniversary, October 10th, Toronto, ON; Session Chair: Biophysics of Cell Behavior
  • 2012-2014 TERMIS-AM Membership Committee
  • 2012 Symposium Organizer “Beyond Borders: Lyon Sachs Symposium on Tissue Engineering and Regenerative Medicine”, Toronto, ON May 08-09
  • 2012 BMES Annual Meeting, October 24th-27th, Atlanta, GA; Session Chair: Cardiovascular Tissue Engineering II
  • 2012 TERMIS World Congress, September 05-08, Vienna, Austria;
    • Session Chair: Cardiac Regeneration
    • Poster Session Chair: Translation in Tissue Engineering and Stem Cell Therapy
    • Poster Session Chair: Cardiac Regeneration
    • Poster Session Chair: Bioreactors for Translational Research
  • 2012 TERMIS World Congress Advisory Board Member
  • 2012 California Institute for Regenerative Medicine Tissue Engineering Workshop (closed, by invitation), Chair: Hydrogels for Cell Delivery & Tissue Repair I, January 11-14, 2012 San Francisco, CA
  • 2011 AIChE Annual Meeting, October 28-November 02, Minneapolis, MN,  Session Chair: Bioreactors In Tissue Engineering
  • 2011 BMES Annual Meeting, October 12-15, Hartford, CT,  Session Chair: Bioreactors and Bioprocessing in Tissue Engineering”
  • 2011 IEEE-EMBC Meeting, August 30th– Sept 3rd,  Boston MA,  Mini-symposium organizer: Electrical Fields at the Cell and Protein Scale
  • 2011 IEEE-EMBC Meeting, August 30th– Sept 3rd,  Boston, MA Program Co-chair for Theme 7 Molecular and Cell Biomechanics, Tissue Engineering, Biomaterials
  • 2010-2012 TERMIS-NA Membership Committee
  • 2010 TERMIS-NA Annual Conference, December 08-08, Orlando, FL, Session Chair: Bioreactor Technologies
  • 2010 AHA Scientific Sessions, November 13-17, Chicago, IL, Session Moderator: Cardiovascular Seminar  CVS.306.Update on Tissue Engineering: What’s Growing?
  • 2010 BMES Annual Meeting, October 06-10, Austin, TX,  Session Chair: Bioreactors and Bioprocessing in Tissue Engineering
  • 2010 Canadian Biomaterials Society Meeting, June 02-04, Kingston, ON, Session Chair: Cardiovascular Biomaterials 1103
  • 2011 Society for Biological Engineering’s Second International Conference on Stem Cell Engineering, May 02-05, 2010, Boston, MA – Poster Session Chair
  • 2009 MRS Fall Meeting, November 30 – December 4, Boston, MA, Session Chair: Engineering Biomaterials for Regenerative Medicine, RR4-Advanced Scaffold Design
  • 2009 AIChE Annual Meeting, November 8-13, 2009, Nashville, TN, Session Co-chair:
    • Biomaterial-Cell Interactions in Tissue Engineering
    • Bioreactors in Tissue Engineering
  • 2009 World Congress of Chemical Engineering, August 23-27, Montreal, QC, Session Co-chair: Biomaterials, Tissue Engineering and Regenerative Medicine (6 and 7)
  • 2008 AIChE Annual Meeting, November 2008, Philadelphia, PA Session Chair, Biomems and Microfluidics: Cell and Biomolecule Analysis (replaced due to pregnancy)
  • 2008 TERMIS EU, June 22-26, Porto, Portugal, Symposium Organizer/Chair: Cardiac Tissue Engineering (replaced due to pregnancy)
  • 2008 World Biomaterials Congress, May 28-June 01, Amsterdam, The Netherlands, Symposium organizer: Young Scientist Forum (replaced due to pregnancy)
  • 2007 AIChE Annual Meeting, November 4-9, Salt Lake City, UT  Session Co-chair:
  • Stem Cells in Tissue Engineering
  • Engineering Fundamentals of Life Sciences Poster Session
  • 2007 AIChE Annual Meeting);  Session Co-chair: Biomems and Microfluidics-Novel Applications, Nov 4-9, Salt Lake City, UT
  • 2007 Annual Meeting of the American Electrophoresis Society (Topical conference at the
  • 2007 TERMIS NA Conference and Exhibition on Tissue Engineering and Regenerative Medicine; Session Co-chair: Cardiac Tissue, June 13th-16th, 2007, Toronto, ON, Canada
  • 2007 Scientific Day Program Committee and Verma Award Selection Panel, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • 2006 ISHR Meeting, North American Section; Session Chair: Tissue Engineering and Nanotechnology in the Heart/Vascular System, June 13-16th, 2006, Toronto, ON
  • 2005 AIChE Annual Meeting; Session Co-chair: Cardiovascular Tissue Engineering, Oct 30-Nov 04, Cincinnati, OH

 

 

DEPARTMENTAL/FACULTY/UNIVERSITY COMMITTEES

  • 2013 Graduate Scholarship Review Committee, Center of Excellence in Cardiovascular Research (HSRLCE), University of Toronto
  • 2013 Internal Reviewer for NSERC Discovery Grants, Institute of Biomaterials and Biomedical Engineering
  • 2013 Tenure Dossier Reviewer, Tufts University
  • 2013-2014 Tenure Committee for Prof. Ofer Levi, Institute of Biomaterials and Biomedical Engineering
  • 2013 Three Year Review Committee for Prof. Arun Ramachandran, Department of Chemical Engineering and Applied Chemistry
  • 2012-2013 IBBME Seminar Series organized visit of
    • Prof. Kursad Turksen, Feb 04th, 2013
    • Prof. Muhammad Yousaf, Feb 28th, 2013
  • 2012-current, Mentor for Prof. Rodrigo Fernandez-Gozales
  • 2012 Graduate Department Academic Appeals Committee (GDAAC), Chemical Engineering and Applied Chemistry
  • 2012 Faculty Search Committee for Department of Chemical Engineering and Applied Chemistry
  • 2011, 2012 Graduate Coordinator-Collaborative Program, IBBME, University of Toronto
  • 2011 Third year review committee for Prof. Alison McGuigan, Department of Chemical Engineering and Applied Chemistry
  • 2011 Faculty Search Committee for IBBME/CCBR faculty position in stem cell bioengineering
  • 2010-2011 Chair Search Committee for Department of Chemical Engineering and Applied Chemistry, Faculty of Applied Science and Engineering, University of Toronto
  • 2010 Reading Committee for a Tenure File, Department of Chemical Engineering and Applied Chemistry, University of Toronto
  • 2010 Post-doctoral Fellowship Review Committee, Center of Excellence in Cardiovascular Research (HSRLCE), University of Toronto
  • 2009-2010 IBBME Graduate Journal Advisory Committee
  • 2010 PTR/Activity Evaluation Committee, IBBME, University of Toronto
  • 2009 Organizer of the Symposium in Honour of Dr. Michael Sefton’s 60th Birthday, University of Toronto
  • 2009 Reviewer, Ontario Post-doctoral Fellowship, University of Toronto
  • 2008 Organizer of the Assistant Professor’s Retreat, Department of Chemical Engineering and Applied Chemistry
  • 2007 PTR/Activity Evaluation Committee, Department of Chemical Engineering and Applied Chemistry, University of Toronto
  • 2007 PTR/Activity Evaluation Committee, IBBME, University of Toronto
  • 2007 IBBME Scientific Day, University of Toronto,  Poster Judge
  • 2007-current Member of the Executive Committee for the REMEDI Project with the budget of $18 million, University Health Network, Toronto
  • 2007-2008, 2009-current Department of Chemical Engineering and Applied Chemistry, Awards and Honours Committee
  • 2007-2008 Faculty of Applied Science and Engineering, member of the Working Group on Branding-defining the new brand for the Faculty
  • 2006-2008 Graduate Studies Committee, Department of Chemical Engineering and Applied Chemistry, University of Toronto
  • 2006 IBBME Scientific Day, University of Toronto,  Poster Judge
  • 2006-current Graduate Recruitment Committee, Department of Chemical Engineering and Applied Chemistry, University of Toronto
  • 2005 Biomaterials Search Committee Faculty of Dentistry/Department of Materials Science and Engineering and IBBME
  • 2005-2009 Member Scientific Advancement Board of Advanced Regenerative Tissue Engineering Centre (ARTEC), Sunnybrook Health Sciences Centre, Toronto

 

EDITORIAL BOARD MEMBER and REVIEWER

Editorial Board:

  • Section Editor-Bioengineering, International Journal of Artificial Organs 2010-2012
  • Editorial Board: Tissue Engineering, 2013-current

Member of review panel:

  • Israeli Council for Higher Education, The Committee for the Evaluation of Biotechnology and Biotechnology Engineering,  2012-2013 (reviewer for Hadassah Academic College, Technion, Ben Gurion University and Tel Aviv University)
  • Heart and Stroke Foundation, Committee V: Molecular Basis of Cardiac and Vascular Function, December 2012
  • NIH Study Section (RO1 and R21): “New Strategies for Growing 3D Tissues”-ZHL CSR-N  (M1 and M2)  March 2011
  • Canadian Institutes of Health Research, Biomedical Engineering Peer Review Panel (CIHR-BME) (Spring 2008, Fall 2010, Spring 2011)
  • Ontario Graduate Scholarship (OGS) Ministry of Training Colleges and Universities (2007-2009)
  • McEwan Centre for Regenerative Medicine Post-doctoral Fellowship Review Panel (2007)

External reviewer:

  • A*STAR, Biomedical Research Council,  Singapore
  • British Foundation Rosetrees Trust
  • Fonazione Cariparo, Italy
  • Fondation pour la Recherche Médicale, France (Bioengineering for Health)
  • Heart and Stroke Foundation of Canada (HSF)
  • Human Science Frontier
  • Israel Science Foundation (ISF)
  • Israeli Ministry of Science
  • National Children’s Research Centre (Ireland)
  • National Science and Engineering Research Council of Canada (NSERC)
  • Sick Kids Hospital, Toronto
  • US-Israel Binational Foundation

Ad hoc reviewer:

  • Acta Biomaterialia
  • Annals of Biomedical Engineering
  • Biofabrication
  • Biomicrofluidics
  • Biomacromolecules
  • Biomaterials
  • BioTechniques
  • Biotechnology &  Bioengineering
  • Biotechnology Progress
  • Cardiovascular Engineering
  • Circulation
  • Circulation Research
  • Current Opinion in Chemical Engineering
  • Current Vascular Pharmacology
  • FASEB Journal
  • Industrial & Engineering Chemistry Research
  • International Journal of Artificial Organs
  • Israel Journal of Chemistry
  • Journal of the American Heart Association
  • Journal of Biomaterials Applications
  • Journal of Biomechanics
  • Journal of Biomedical Materials Research Part A
  • Journal of Biomedical Materials Research Part B
  • Journal of Cellular Physiology
  • Journal of Theoretical Biology
  • Lab on a Chip
  • Langmuir
  • Materials Today
  • Nature Biotechnology
  • Nature Communications
  • Nature Materials
  • Nature Methods
  • Nature Protocols
  • Neurological Research
  • PNAS
  • Proceedings of the Materials Research Society
  • Science Translational Medicine
  • Soft Matter
  • Stem Cell Research
  • Stem Cell Research and Therapy
  • Trends in Cardiovascular Medicine

 

 PUBLIC AWARENESS/EDUCATION

  • Featured on “ Canadian Women of Innovation” web-site  created by  the Canada Science and Technology Museum in Ottawa, Ontario, Canada in partnership with Engineers Canada
    http://www.women-innovation.technomuses.ca/
  • “Developing therapies for replacing damaged heart tissue vs. endogenous repair”, Let’s Talk Science, Stem Cell Talks, Toronto, ON, March 09th, 2012
  • “Managing students, time and money” presentation to Prospective Professors in Training  Program, University of Toronto, Faculty of Applied Science and Engineering, January 30th, 2012
  • “Engineered Heart Tissue”,  Department of Chemical Engineering and Applied Chemistry, University of Toronto, Research Days,  Jan 26th, 2012
  • Galbraith Society Mentor, University of Toronto, mentoring 4 undergraduate students 2011-2012
  • “Cardiac Tissue Engineering” presentation to the Club for Undergraduate Biomedical Engineering, University of Toronto,  October 17, 2011
  • Let’s Talk Science Lab Tours and Outreach, May 19, 2009 and 2010 Forty students grade 7-8 attended the lab tours. We showed them beating cardiac tissue and H&E stained slides of sectioned hearts.
  • “Engineered Heart Tissue” presentation for Graduate Recruitment weekend Department of Chemical Engineering and Applied Chemistry, Jan 28th, 2011
  • Science Randez-vous, May 09, 2009 and 2010. We participated and helped organize the demonstrations for the University-wide event focused on raising awareness about science. During Science Randez-vous, the University is open to the public and it is estimated that thousands of people bring their children to this even every year.
  • CAIGS visit, Department of Chemical Engineering and Applied Chemistry, April 07, 2009 We showcased our lab to the Canadian Association of Girls in Science.
  • Youth Outreach, April 14, 2009 Organized a full day of laboratory demonstrations for high school students from the Hill Academy in Kleinburg, Ontario.  Sponsored by the Youth Outreach Funds from my Early Researcher Award. The teacher was Stacy Shulz and 18 students attended
  • Winter 2008-2012 Chemical Engineering Research Days. Presentation to Chemical Engineering undergraduate students, University of Toronto.
  • Summer 2006 Institute of Biomaterials and Biomedical Engineering. Seminar to the Summer Students in IBBME, University of Toronto, on cardiac tissue engineering, most of whom were the undergraduate students of the University of Toronto.
  • Appeared on TVOntario show More2Life with Mary Ito. Topic: Women in Science, Jan 06, 2006.
  • Featured on the cover of “Changing our world: The Stories of Women Engineers” (Feb 2006). This is a flagship book of an outreach program sponsored by 55 US institutions aimed at increasing the enrolment of women in engineering http://www.engineeringwomen.org/

 

SELECTED MEDIA FEATURES

  • “Heart tissue is grown from rat heart cells” Associated Press, Dec 14, 2004
  • “Heart patch pulses like the real thing” – study Reuters, Dec 14, 2004
  • “Beating heart tissue grown in lab” BBC News, Dec 15, 2004
  • “Electrical Signals Key to Culturing Heart Tissue” Scientific American, online, Dec 14, 2004
  • “MIT grows beating heart tissue” Boston Globe, Dec 14, 2004
  • “Engineered grow heart tissue that mends broken hearts” MIT TechTalk Dec 15, 2004
  • “Rebuilding broken hearts” The Toronto Star, Sept 27th , 2004
  • “How to fix a broken heart in ten easy steps” The Varsity, Apr 17th, 2003
  • “Tissue engineering: The beat goes on” Nature, Feb 27;421(6926):884-6. 2003 
  • “Rebuilding Site: Bioactive scaffolds combine physical support with biological activity” WellcomeScience Issue 2, pg 10-11, March 2006,
  • Brochure, Department of Chemical Engineering, McMaster University (Fall 2005); Interfaces, Department of Chemical Engineering, University of Toronto (Spring 2006).
  •  “Transplants made to order” The Scientist, 20 (9) 35,  Sept 2006
  • Interview at www.regenerativemedicinetoday.com (#35) July 17, 2007
  • “Top 35 Innovators under 35”, M.I.T. Technology Review, September/October 2008
  • “ Technology Review names U of T’s Radisic top innovator”, University of Toronto Homepage on
  • August 19th, 2008
  • “Leading Edge: Healing the heart”, UofT Magazine, Winter 2009
  • “Radisic named top innovator”, The Bulletin, September 9, 2008
  • “A roundup of award news”, Engineering Dimensions, Magazine of the Professional Engineers of Ontario, November/December 2008 Volume 29, No.6
  • Featured in the 2007-2009 Report by the Heart and Stroke Richard Lewar Centre of Excellence
  • Interview in Serbian daily newspaper “Politika”, 04/04/2009
  • Awards and Honours, WISE Award, The Bulletin, University of Toronto, September 29, 2009
  • “Help for Broken Hearted” PEO Engineering Dimensions Magazine, September/October 2009, p. 44
  • “U of T researchers define barriers to successful heart cell transplants”, University of Toronto News, October 22, 2009
  • “25 Ideas that are changing the world” by the Toronto Life Magazine, December 2009 (Idea# 13 featured on the cover)
  • Interview on CanadaAM December 03, 2009
  • 2010’s People to Watch, Toronto Star, Jan 03, 2010
  • “Scientist to Watch Milica Radisic: Mending Broken Hearts”, The Scientist, June 2010
  • “Mentoring: On the right path”  Nature, 474:667-669, June 2011
  • “How to fix canada”, Sharp, Canada’s Largest Magazine for Men, September, 2011

 

HIGHLIGHTED ARTICLES

  • Nunes et al Nature Methods 2013 highlighted by SciBX 6(29); doi:10.1038/scibx.2013.774: “Platform for maturation of human pluripotent stem cell–derived cardiomyocytes
  • Iyer et al Biofabrication 2012 featured in the journal’s Highlight’s Collection during 2012
  • Leng et al Advanced Materials 2012 got the July 17, 2012 Cover
  • Leng et al Advanced Materials 2012 featured in Lab on a Chip Research Highlights, August 2012
  • Al-Haque et al Macromolecular Bioscience 2012 got the October Cover
  • Zhang et al Nanotechnology has been downloaded 250 times in one month since on-line publication on Dec 09th.  To put this into context, across all IOP journals 10% of articles were accessed over 250 times in the last quarter of 2011.
  • Bhana et al Biotechnology & Bioengineering got the June Cover in 2011
  • Vunjak-Novakovic G et al “Challenges in tissue Engineering” was  one of most downloaded articles in Tissue Engineering journal  for December 2010
  • Chiu et al Tissue Engineering Part A got the June Cover
  • Radisic et al Tissue Engineering 2009 republished in book on Advances in Tissue Engineering
  • Chiu et al Molecular Bioscience 2010 got the issue’s Frontispiece
  • Song et al PNAS 2010  in Cell Therapy News on November 23, 2009
  • Song et al PNAS 2010 featured in Vascular Biology Publications Alert by North American Vascular Biology Organization on March 23, 2010
  • Plouffe et al Lab on a Chip 2009 listed as Hot Article on journal web-site, Spring 2009
  • Brown et al article published in Biotechnology Progress was one of the top 10 downloaded articles from the journal web-site in the month of January 2009.  As a result Biotechnology Progress featured our article (Brown et al) in their e-mail on Friday, January 30, 2009
  • October 2008 Blueprint for Growing Heart Tissue: Our research on electrical field stimulation was featured in “Advancing Tissue Science and Engineering”, the strategic plan for tissue science and engineering, prepared by the Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group of the National Science and Technology Council (NSTC). This document is a strategic plan for US Federal Government investments in tissue science and engineering. NSTC is a cabinet-level council by which the US President coordinates science, space and technology policies across the Federal Government. http://www.tissueengineering.gov/welcome-s.htm
  • Freed et al Tissue  Eng, 2006 review paper was the 3rd most read article in the journal for the period June 2006-June 2007
  • Cardiac tissue engineering work was highlighted at the NIBIB Council by the Director Roderic I. Pettigrew  (Spring 2006)
  • Cardiac tissue engineering work featured on the NIBIB web-site May 31, 2006 http://www.nibib.nih.gov/HealthEdu/PubsFeatures/eAdvances/31May06
  • Radisic et al 2006 review article in the International Journal of Nanomedicine is the only article made free the Editor and Publisher of this journal.
  • Radisic et al 2006 featured on the cover of Tissue Eng 12(8) 2006
  • Park et al 2005 highlighted by the Editor in In Vitro Cell Dev Biol Animal 41(7) 2005
  • Radisic et al 2004 featured in Advancing Tissue Science and Engineering, a strategic plan of the Multi-Agency Tissue Engineering Science (MATES) Working Group of the National Science and Technology Council (NSTC)
  • Radisic et al 2004 highlighted on the cover of Proc Natl Acad Sci USA 101 (52)

 

RESEARCH FUNDING

Agency Period Project Title/PI
National Institutes of Health (NIH) (USA) 2005-2010 Engineering Vascularized MyocardiumPI: G. Vunjak-Novakovic
Ontario Research Development Challenge Fund (ORDCF) 2005-2009 Advanced Regenerative Tissue Engineering Centre (ARTEC)PI: J. Semple, K. Woodhouse +4 others “Tissue engineering of a functional cardiac patch based on peptide modified chitosan scaffold”PI: M. Radisic
University of Toronto Connaught Start-Up Award 2005-2007 Advanced Bioreactor for Functional Tissue EngineeringPI: M. Radisic
CFI Leaders Opportunity Fund / ORF-RI 2006-2008 Laboratory for Functional Tissue Engineering PI: M. Radisic
NSERC Discovery Grants -Individual 2006-2010 Advanced Bioreactors for Functional Tissue Engineering of MyocardiumPI: M. Radisic
New Staff Matching GrantConnaught Fund, University of Toronto 2006-2008 Resident Cardiac Progenitor Cell for Tissue Engineering ApplicationsPI: M. Radisic
Dean of Medicine-New Staff Grants, University of Toronto 2006-2011 Photocrosslinkable biomaterial for cell injection and cardiac tissue engineeringPI: M. Radisic
Turner Biosystems Grants Program 2007 Turner Biosystems Fluorometer  (TSB-380) GrantPI: C. Simmons
American Health Assistance FoundationNational Heart Foundation 2007-2009 Microscale Isolation of Cardiac Progenitor CellsPI: S. Murthy
CFILeading Edge Fund 2007-2010 The Regenerative Medicine ProjectPI:  R. Weisel
CFIInfrastructure Operating Fund 2007-2010 Laboratory for Functional Tissue EngineeringPI: M. Radisic
CIHRRegenerative Medicine and Nanomedicine Team Grant 2006-2011 The Cardiac Regeneration (CARE) Project PI: R. Weisel
Heart and Stroke Foundation(Grant-in-Aid) 2007-2010 “Peptide modified photocrosslinkable chitosan for cell therapy in myocardialinfarction”PI: M. Radisic, Co-Is: R-K Li, M Rupnick
Juvenile Diabetes Research FoundationInnovative Grant 2007-2008 In vitro model system for cardiac cell therapy in diabetic patients”PI: M. Radisic, co-PI: P. Zandstra
Early Researcher AwardMinistry of Research (ERA) and Innovation, Ontario 2007-2012 “Functional cardiac patch based on resident cardiac progenitor cells”PI: M. Radisic
Ontario Centers of Excellence 2008-2009 “Biomaterials with growth factor gradients for cardiac cell therapy”PI: M. Radisic, Co-PI: M. Shoichet
NSERC Research Tools and Instrumentation 2008-2009 Real Time PCR for Advanced Tissue EngineeringPI: M. Shoichet; Co-Is: C. Morshead, M. Radisic
Heart and Stroke Foundation(Grant-in-Aid) 2009-2013 “Interrogating the cardiomyogenic hierarchy to optimize cardiovascular
cell therapy”PI: P. Zandstra; Co-I: M. Husain, K. Nanthakumar, M. Radisic
NSERC CREATE 2009-2015 NSERC CREATE Program in Microfluidic Applications and Training in
Cardiovascular HealthPI: M. Sefton +9 Co-Is (C. Simmons, A. Guenther, M. Radisic etc.)
CFINew Initiatives Fund 2009-2012 Centre for Microfluidic Systems in Chemistry and BiologyPI: M. Sefton, A. Guenther
NSERCStrategic Projects 2009-2012  “Engineering vascular networks by site specific differentiation of angiogenic progenitor cells”PI: M. Radisic, co-I: M. Sefton, W. Stanford
HSFOGrant-in-Aid 2010-2014 “Chitosan hydrogel with immobilized growth factors for cell therapy in myocardial infarction”PI: M. Radisic, co-I:  R-K Li
NSERCDiscovery Grant 2010-2015 “Cardiac tissue engineering and cell separation”PI: M. Radisic
NSERCDiscovery Accelerator Supplement 2010-2013 “Processing and design criteria for engineering artificial tissues”PI: M. Radisic
ORFGL2 2009-2013 “Cardiovascular biomarker discovery in disease and development through predictive precision proteomics (CBD3P3)”PIs: P. Liu and G. Keller, co-Is: A. Gramolini, T. Kislinger, P. Zandstra, M. Radisic, S. Mital, J. Coles
NIHRO1 2010-2014 Microfluidic Cell Separation for Tissue Engineering and Regenerative MedicinePI: S. Murthy, co-I. R. Carrier, M. Radisic, V. Sales/J. Mayer, Y. Nahmias/M. Yarmush
NSERC-CIHRCHRP 2010-2014 Tissue engineered patches for the repair of cardiovascularcongenital malformationsPI: M. RadisicCo-I: Li R-K, Stanford WL
Connaught Fund, University of Toronto 2011 Application of QHREDGS peptide in survival and expansion of human stem cells and their cardiovascular progenyPI: M. Radisic
NSERC Engage 2011 Peptide functionalized bone implant coatings for improved osteogenesisPI: M. Radisic
Canada Research Chair (Tier 2) 2011-2016 Functional Cardiovascular Tissue EngineeringPI: M. Radisic
CFI-LOF 2013 Laboratory for Cardiovascular Tissue EngineeringPI: M. Radisic
ORF 2013 Laboratory for Cardiovascular Tissue EngineeringPI: M. Radisic
NIH UH2 2012-2017 Integrated heart-liver-vascular systems for drug testing in human health and diseasePI: G. Vunjak-NovakovicCO-Is:C. ChenS. BhatiaK. Hirshi(M. Radisic)
NIH RO1 2013-2018 Engineering Vascularized MyocardiumPI: G. Vunjak-NovakovicCo-I: M. Radisic
NSERC I2I 2012 -2013 Device for cell separation based on manipulation of settling velocityPI: M. Radisic
NSERC CREATE 2013-2018 NSERC CREATE training program in manufacturing, materials and mimetics (M3)PI: M. Shoichet(+9co-PIs including Radisic)
CIHR Operating Grant 2013-2017 Engineering Microenvironments for Cardiac RegenerationPI: M. RaidiscCo-I: K. Nanthakumar, G. Keller
McLean Award 2013-2017 Cardiovascular tissue engineering
Peter Munk Cardiac Center Innovation Committee 2013-2014($65,000 for MR) Personalized Antiarrhythmic Therapy using iPS cells in a Novel Arrhythmia in Dish TechniquePI: K. NanthakumarCo-I: M. Radisic, G. Keller, P. Backx
E.W.R. Steacie Memorial Fellowship 2014-2016 Recreating nature’s tapestry in the lab: biomaterials for induction of fractal tubulogenesisPI: M. Radisic

 

COURSES

Role/Period Subject/curriculum Duties/Purpose
InstructorFall 2010 JTC 1331 Biomaterials Coordinate and teach in a multi-instructor graduate course focused on biomaterials, host response and applications of biomaterials in tissue engineering and regenerative medicine
InstructorWinter 2010Winter 2011 CHE210 Heat and Mass Transfer(2th year course, 120 students) Taught fundamentals of heat and mass transfer: conduction, diffusion, convection, steady state and transient problems, 1D and 2D. Heat exchangers. Convective heat/mass transfer coefficient correlations. Simultaneous heat and mass transfer. Mass transfer between phases.
InstructorWinter 2007Winter 2008Fall 2009 CHE466  Bioprocess Engineering(4th year course, 28 students) Designed a new tissue culture laboratory. Taught material relevant to bioreactor design, fermentations, bioseparations, tissue culture and waste-water treatment.
InstructorWinter 2007Winter 2008Winter 2010Winter 2011 BME105 Systems Biology(1st year course, 270 students) Taught a course section covering material in cell biology (cell structure, cell membrane and transport across  the membrane)
InstructorFall 2005 CHE353 Engineering Biology (3rd year course,  180 students School of Engineering) Designed a course section to examine cell structure and transport across cell membrane
Teaching Lab Supervisor2007-2008 IBBME Teaching Lab Faculty Supervisor IBBME offers labs for 18 different courses to over 1000 students. Roles to ensure 1) that all safety certificates are in place 2) that the labs are scientifically and practically sound and 3) that the cost is within the allocated budget.
Guest LecturerWinter 2007Winter 2008 BME395 Molecular Bioengineering(3rd year course, ~70students) Gave 2 hrs of lectures on cardiac tissue engineering: advances and challenges
Guest LecturerWinter 2008Winter 2009Fall 2009 BME1450 Introduction to Bio-Engineering (Graduate Course, IBBME ~100 students) Gave 1 hr lecture on cardiac tissue engineering
Guest LecturerWinter 2009 PPIT Prospective Professors in Training Managing students, time and money
Teaching AssistantFall 2003 Introduction to Chemical Engineering, MIT (Instructors: Sawin/Stephanopoulos) Help session instruction, preparation of homework and test solutions, exam review sessions (20hr/week)