Refereed Journal Papers

Published: (after line at the University of Toronto)

Refereed Journal Papers:

  1. Ahadian S, Davenport-Huyer L, Estili M, Yee B, Smith N, Xu Z, Sun Y, Radisic M: “Moldable elastomeric polyester-carbon nanotube scaffolds for cardiac tissue engineering”, Acta Biomaterialia, S1742-7061(16)30678-X. doi: 10.1016/j.actbio.2016.12.009, 2016
  2. Xiao Y, Feric NT, Knee EJ, Gu J, Cao S, Laschinger C, Londono C, McGuigan AP, Radisic M: “Diabetic wound regeneration using peptide-modified hydrogels targeting the epithelium”, Proceedings of the National Academy of Sciences of the United States of America, 113(40):E5792-E5801, 2016
  3. Massé S, Magtibay K, Jackson N, Asta J, Kusha M, Zhang B, Balachandran R, Radisic M, Deno DC, Nanthakumar K: “Resolving Myocardial Activation with Novel Omnipolar Electrograms”, Circulation: Arrhythmia and Electrophysiology, 9(7):e004107, 2016
  4. Nunes SS, Feric N, Pahnke A, Miklas JW, Li M, Coles J, Gagliarde M, Keller G, Radisic M: “Human stem cell-derived cardiac model of chronic drug exposure” ACS Biomaterials Science & Engineering, DOI: 10.1021/acsbiomaterials.5b00496 April 13, 2016
  5. Davenport-Huyer L, Zhang B, Korolj A, Montgomery M, Drecun S, Conant G, Zhao Y, Radisic M: “A highly elastic and moldable polyester biomaterial for cardiac tissue engineering applications”, ACS Biomaterials Science & Engineering, 2:780–788, 2016
  6. Zhang B, Montgomery M, Chamberlain MD, Ogawa S, Korolj A, Pahnke A, Wells LA, Massé S, Kim J, Reis L, Momen A, Nunes SS, Wheeler AR, Nanthakumar K, Keller G, Sefton MV, Radisic M: “Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis”, Nature Materials, doi: 10.1038/nmat4570, 15:669-78, 2016 (featured in Toronto Star, CBC The National etc. Upon publication ranked in the 99 percentile (445th) of the 130,020 tracked articles of a similar age in all journals. Cover article)
  7. Zhang B, Montgomery M, Davenport-Huyer L, Korolj A, Radisic M.: “Platform technology for scalable assembly of instantaneously functional mosaic tissues.” Science Advances 1(7):e1500423, 2015 (featured on Vice Motherboard, The Times of India, Gizmodo, Popular Science, New Scientist, Yahoo.ca, Gizmag, The Scientist, CityNews at 6 etc)
  8. Xiao Y, Reis L, Zhao Y, Radisic M: “ Modifications of biomaterials with immobilized growth factors or peptides for tissue engineering applications” Methods, 2S1046-2023(15)00172-3, 2015.
  9. Kana K, Song H, Laschinger C, Zandstra PW, Radisic M: “PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System”, Tissue Engineering Part A, 2015 17-18, 2379-2389, 2015
  10. Hsieh A, Feric NT and Radisic M (corresponding author): “Combined hypoxia and sodium nitrite pretreatment for cardiomyocyte protection in vitro”, Biotechnology Progress, Apr, 482-492, 2015
  11. Reis LA, Chiu LLY, Wu J, Feric N, Lachinger C, Momen A, Li R-K, Radisic M (corresponding author): “Hydrogels with integrin binding angiopoietin 1 derived peptide QHREDGS for treatment of acute myocardial infarction”, Circulation- Heart Failure, 8:333-41, 2015
  12. Feric N, Cheng C, Coh C, Yang L, Di Tizio V, Radisic M (corresponding author): “QHREDGS promotes osteoblast differentiation, bone matrix deposition and mineralization”, RSC Biomaterials Science, 2, 1384-1398, 2014
  13. Dang LT, Feric N, Laschinger C, Chang WY, Zhang B, Wood G, Stanford WL, Radisic M (corresponding author):” A biomaterials-based approach to inhibit apoptosis of human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS”, Biomaterials, 35:7786-99, 2014
  14. Traister A, Li M, Aafaqi S, Lu M, Arab S, Radisic M, Guido F, Sherret J, Verma S, Slorach C, Mertens L, Hui W, Hannigan G, Maynes JT, Coles JG: “Rescue of disrupted mechanotransduction as a new therapeutic strategy in human dilated cardiomyopathy” Nature Communications, Sep 11;5:4533. doi: 10.1038/ncomms5533, 2014
  15. Miklas JW, Nunes SS, Pahnke A, Sofla A, Radisic M: “Bioreactor for modulation of cardiac microtissue phenotype by combined mechanical and electrical stimulation” Biofabrication, 6(2):024113. doi: 10.1088/1758-5082/6/2/024113, 2014
  16. Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y : “In situ mechanical characterization of the cell nucleus by atomic force microscopy”, ACS Nano, 8:3821-8, 2014
  17. Thavandiran N,  Dubois  D, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande V, McGarry P, Chen CS, Nanthakumar K,  Keller G, Radisic M (co-corresponding author), Zandstra PW: “Design criteria-quided formulation of pluripotent stem cell-derived cardiac microtissues” Proceedings of the National Academy of Sciences of the United States of America  110(49):E4698-707. doi: 10.1073/pnas.1311120110, 2013
  18. Xiao Yun, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons CA, Keller G, Radisic M (corresponding author): “Microfabricated perfusable cardiac biowire: a platform that  mimics native cardiac bundle” 2013 Dec 19. [Epub ahead of print]
  19. Miklas JW, Dallabrida SM, Reis LA, Ismail N, Rupnick M, Radisic M (corresponding author): “QHREDGS enhances tube formation, cell metabolism and cell survival of human umbilical cord endothelial cells in collagen-chitosan hydrogels” PLoS One, 8(8):e72956, 2013 doi:10.1371/journal.pone.0072956
  20. Zhang B, Peticone C, Murhty S, Radisic M (corresponding author): “A standalone perfusion platform for drug testing in microvessel networks “ Biomicrofluidics 7, 044125 (2013); http://dx.doi.org/10.1063/1.4818837
  21. Redpath CJ, Bou Khalil M, Drozdzal G, Radisic M, McBride HM: “Mitochondrial hyperfusion during oxidative stress is coupled to a dysregulation in calcium handling within a C2C12 cell model”  PLoS One 8;8(7):e69165, 2013 doi: 10.1371/journal.pone.0069165
  22. Nunes SS, Miklas JW, Xiao Y, Zhang B, Hsieh A, Thavandiran N, Jiang J, Masse S, Ggaliardi M, Laflamme MA, Nanthakumar K, Gross G, Keller G, Radisic M (corresponding author): “Biowire: a platform for maturation of human pluripotent stem cell derived cardiomyocytes” Nature Methods 10:781-787, 2013 (On July 03rd, 2013 the article ranked in the 98 percentile of a sample of 10,000 of the 31,524 tracked articles of a similar age in all journals and  in the 95 percentile (ranked 3rd) of the 46 tracked articles of a similar age in Nature Methods)
  23. Sofla A, Cirkovic B, Hsieh A, Miklas JW, Filipovic N, Radisic M (corresponding author): “Enrichment of live unlabelled cardiomyocytes from heterogeneous cell populations using manipulation of cell settling velocity by magnetic field” Biomicrofluidics 7, 014110, 2013;  http://dx.doi.org/10.1063/1.4791649
  24. Martin C, Sofla AYN, Zhang B, Nunes SS, Radisic M (corresponding author):“Fusible core molding for fabrication of branched three-dimensional perfusable microvessels for vascular tissue engineering” International Journal of Artificial Organs, 36:159-65, 2013
  25. Chiu LLY, Montgomery M, Liang Y, Liu H, Radisic M (corresponding author): “Perfusable branching microvessel bed for vascularization of engineered tissues”, Proceedings of the National Academy of Sciences of the United States of America, 109:E3414-23, 2012
  26. Kang K, Sun L, Xiao Y, Li S-H, Wu Y, Yau TM, Weisel RD, Radisic M, Li R-K : “Aged Human Cells Rejuvenated by Cytokine-Enhancement of Biomaterials for Surgical Ventricular Restoration”,  Journal of the American College of Cardiology,  20:2237-49, 2012
  27. Chiu LLY, Reis LA,  Momen A, Radisic M (corresponding author): “Controlled release of thymosin β4 from injected collagen-chitosan hydrogels promotes angiogenesis after myocardial infarction in rats” Regenerative Medicine,  7:523-33, 2012
  28. Iyer TK,  Chiu LLY, Vunjak-Novakovic G, Radisic M (corresponding author): “Sequential Preculture of Non-Myocytes Improves Formation of Vascular-Like Cords in Engineered Cardiac Tissues” Biofabrication  4:035002, 2012
  29. Al-Haque S, Miklas J, Feric N, Chiu LLY, Chen WLK, Simmons CA, Radisic M (corresponding author): “Substrate stiffness and topography simultaneously influence cardiac fibroblast contact guidance on hydrogels “ Macromolecular Bioscience, 12:1342-53, 2012 (cover article)
  30. Leng L, McAllister A, Zhang B, Radisic M, Günther A: “Mosaic hydrogels: One-step formation of multidimensional, multiscale soft materials” Advanced Materials, 24:3650-8, 2012 (cover article)
  31. Zhang B, Green JV, Murthy SK, Radisic M (corresponding author): “Label-free enrichment of functional cardiomyocytes using microfluidic deterministic lateral flow displacement” PLoS One 2012;7(5):e37619. Epub 2012 May 29.
  32. Iyer RK, Odedra D, Vunjak-Novakovic G, Radisic M (corresponding author): “VEGF Secretion by Non-Myocytes Modulates Connexin-43 Levels in Cardiac Organoids” Tissue Engineering Part A, 18:1771-83, 2012
  33. Chiu LLY, Janic K, Radisic M (corresponding author): “Engineering of oriented myocardium on three-dimensional micropatterned collagen-chitosan hydrogel”,  International Journal of Artificial Organs, 35:237-250, 2012
  34. Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS: “A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues” Tissue Engineering Part A. (9-10):910-9, 2012
  35. Reis LA, Chiu LL, Liang Y, Hyunh K, Momen A, Radisic M (corresponding author): “A peptide-modified chitosan-collagen hydrogel for cardiac cell culture and delivery” Acta Biomaterialia, 8:1022-36, 2012
  36. Chiu LLY, Radisic M (corresponding author): “Controlled release of thymosin β4 using collagen-chitosan composite hydrogels promotes epicardial cell migration and angiogenesis”, Journal of Controlled Release,  155:376-85, 2011
  37. Chiu LLY, Iyer RK, Radisic M (corresponding author): “Biphasic electrical field stimulation aids in tissue engineering of multi-cell type cardiac organoids” Tissue Engineering Part A, 17:1465-77, 2011
  38. Odedra D, Shoichet M, Radisic M (co-corresponding author): “Endothelial Cells Guided by Immobilized Gradients of Vascular Endothelial Growth Factor on Porous Collagen Scaffolds”,  Acta Biomaterialia,7:3027-35, 2011
  39. Song H, Zandstra P, Radisic M (corresponding author): “Engineered heart tissue model of diabetic myocardium.”,  Tissue Engineering, (13-14):1869-78, 2011
  40. Miyagi Y and Chiu LLY, Cimini M,  Weisel RD, Radisic M (co-corresponding author), Li R-K  “Biodegradable collagen patch with covalently immobilized VEGF improves right ventricular repair” Biomaterials, 32:1280-90, 2011
  41. Dengler J, Song H, Massé S, Wood G, Nanthakumar K, Zandstra PW and Radisic M (corresponding author): “An in vitro model system for cardiac stem cell therapy” Biotechnology & Bioengineering , 108: 704-719, 2011
  42. Rask F, Mihic A, Reis L, Dallabrida SM, Ismail NS, Sider K, Simmons CA, Rupnick MA, Weisel RD, Li R-K, Radisic M (corresponding author): “Hydrogels modified with QHREDGS peptide support heart cell survival in vitro and after sub-cutaneous implantation”  Soft Matter,  6:5089-5099, 2010
  43. Chiu LLY, Weisel RD, Li R-K, Radisic M (co-corresponding author): “Defining conditions for covalent immobilization of angiogenic growth factors onto scaffolds for tissue engineering” Journal of Tissue Engineering and Regenerative Medicine 5:69-84, 2011
  44. Bhana B and  Iyer RK, Chen WLK, Zhao R, Sider KL, Simmons CA, Radisic M (corresponding author): “Influence of Substrate Stiffness on the Phenotype of Heart Cells” Biotechnology and Bioengineering, 105:1148-1160, 2010 (cover in June 2011)
  45. Rask F, Dallabrida SM, Ismail NS, Amoozgar Z, Yeo Y, Rupnick M,  Radisic M. (corresponding author): “Photocrosslinkable chitosan modified with angiopoietin-1 peptide, QHREDGS, promotes survival of neonatal rat heart cells” Journal of Biomedical Materials Research Part A, 95:105-117, 2010
  46. Chiang K, Chowdhury MF, Iyer RK, Stanford WL, Radisic M (co-corresponding author): “Engineering surfaces for site specific vascular differentiation of mouse embryonic stem cells” Acta Biomaterialia, 6:1904-16, 2010
  47. Song H, Yoon C, Kattaman SJ,  Dengler J, Thavaratnam T, Gewarges M, Masse S,  Nanthakumar K, Rubart M, Keller GM, Radisic M (co-corresponding author), Zandstra P: “Interrogating functional integration between injected pluripotent stem cell derived-cells and surrogate cardiac tissue” Proceedings of the National Academy of Sciences of the United States of America, 107:3329-3334, 2010
  48. Chiu LLY, Radisic M (corresponding author): “Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues” Biomaterials, 31:226-241, 2010
  49. Green JV, Radisic M,  Murthy SK: “Deterministic Lateral Displacement as a Means to Enrich Large Cells for Tissue Engineering”  Analytical Chemistry, 81:9178-9182, 2009
  50. Plouffe BD, Brown MA, Iyer RK, Radisic M (co-corresponding author), Murthy SK: “Controlled Capture and Release of Cardiac Fibroblasts using Peptide-Functionalized Alginate Gels in Microfluidic Channels”, Lab on a Chip, 9:1507-10, 2009
  51. Iyer RK, Chui J, Radisic M. (corresponding author): “Spatiotemporal tracking of cells in tissue-engineered cardiac organoids.” Journal of Tissue Engineering and Regenerative Medicine, 3:196-207, 2009
  52. Heidi Au HT, Cui B, Chu ZE, Veres T, Radisic M. (co-corresponding author):  “Cell culture chips for simultaneous application of topographical and electrical cues enhance phenotype of cardiomyocytes” ,  Lab on a Chip,  9:564-575, 2009
  53. Tandon N, Cannizzaro C, Chao PH, Maidhof R, Marsano A, Au HT, Radisic M, Vunjak-Novakovic G. “Electrical stimulation systems for cardiac tissue engineering” Nature Protocols, 4:155-173, 2009
  54. Park H, Bhalla R, Saigal R, Radisic M, Watson N,  Langer R, Vunjak-Novakovic G. “Effects of electrical stimulation in C2C12 muscle constructs” Journal of Tissue Engineering and Regenerative Medicine 2:279-287, 2008
  55. Brown MA, Iyer RK, Radisic M (corresponding author): “Pulsatile perfusion bioreactor for cardiac tissue engineering”, Biotechnology Progress, 24:907-920, 2008
  56. Radisic M (co-corresponding author), Fast VG, Sharifov OF, Iyer RK, Park H, Vunjak-Novakovic G: “Optical mapping of impulse propagation in engineered cardiac tissue” Tissue Engineering Part A, 15:851-60, 2009
  57. Iyer RK, Chiu L, Radisic M (corresponding author): “Microfabricated poly(ethylene glycol) templates enable rapid screening of tri-culture conditions for cardiac tissue engineering” Journal of Molecular and Cellular Cardiology 40: 877, 2006
  58. Shen Y-H, Shoichet M, Radisic M (corresponding author): “Vascular endothelial growth factor immobilized in collagen scaffold promotes proliferation and penetration of endothelial cells” Acta Biomaterialia,  4:477-489, 2008Journal of Biomedical Materials Research Part A, 89A:616-31, 2009
  59. Plouffe BD, Radisic M, Murthy SK: “Microfluidic Depletion of Endothelial Cells, Smooth Muscle Cells, and Fibroblasts from Heterogeneous Suspensions” Lab on a Chip, 3:462-472, 2008
  60. Radisic M, Marsano A, Maidhof R, Wang Y, Vunjak-Novakovic G. “Cardiac tissue engineering using perfusion bioreactor systems” Nature Protocols, 3:719-38, 2008
  61. Radisic M, Park H, Salazar-Lazaro JE, Wang Y, Langer R, Freed LE, Vunjak-Novakovic G: “Pretreatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue” Journal of  Biomedical Materials Research Part A, 86:713-724, 2008
  62. Wallis MC, Yeger H, Cartwright L, Shou Z, Radisic M, Haig J, Suoub M, Farhat WA: “Feasibility study of a novel urinary bladder bioreactor” Tissue Engineering,14:339-348, 2008
  63. Au HTH, Cheng I, Chowdhury MF, Radisic M (corresponding author): “Interactive effects of surface topography and pulsatile electrical field stimulation on fibroblasts and cardiomyocytes” Biomaterials, 28: 4277-93, 2007
  64. Murthy SK, Sethu P, Vunjak-Novakovic G, Toner M, Radisic M (corresponding author): “Size-Based Microfluidic Enrichment of Neonatal Rat Cardiac Cell Populations” Biomedical Microdevices, 8:231-237, 2007
  65. Khademhosseini A, Eng G, Yeh J, Kucharczyk PA, Langer R, Vunjak-Novakovic G, Radisic M (corresponding author): “Microfluidic patterning for fabrication of contractile cardiac organoids” Biomedical Micordevices, 9:149-157, 2007
  66. Plouffe BD, Njoka D, Harris J, Liao J, Horick NK, Radisic M, Murthy SK: “Peptide-Mediated Selective Adhesion of Smooth Muscle and Endothelial Cells in Microfluidic Shear Flow” Langmuir, 23:5050-5055, 2007
  67. Yeo Y, Geng, W, Ito T, Kohane DS, Burdick JA, Radisic M (corresponding author): “A photocrosslinkable hydrogel for myocyte cell culture and injection” Journal of Biomedical Materials Research Part B, 81:312-322, 2006
  68. Karp JM, Yeo Y, Geng W, Cannizarro C, Jan K, Kohane DS, Vunjak-Novakoviv G, Langer RS, Radisic M (corresponding author): “A Photolitographic Method to Create Cellular Micropatterns” Biomaterials 27:4755-64, 2006
  69. Radisic M , Park H, Chen F, Wang Y, Dennis R, Langer R, Freed LE, Vunjak-Novakovic G: “Biomimetic approach to cardiac tissue engineering: Oxygen carriers in channeled scaffolds” Tissue Engineering, 12: 2077-91, 2006 (Cover article)
  70.  Radisic M , Malda J, Epping E, Geng W, Langer R, Vunjak-Novakovic G: “Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue” Biotechnology and Bioengineering, 93:332-343, 2006
  71. Park H, Radisic M, Lim JO, Chung BH, Vunjak-Novakovic G: “A novel composite scaffold for cardiac tissue engineering” In Vitro Cell and Developmental Biology-Animal,41:188-196, 2005
  72. Boublik J, Park H, Radisic M, Tognana E, Chen F, Pei M, Vunjak-Novakovic G, Freed LE: “Mechanical function and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and a biodegradable, elastomeric knitted fabric” Tissue Engineering, 11: 1122-1132, 2005
  73. Radisic M , Deen WM, Langer R, Vunjak-Novakovic G: “Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers” American Journal of Physiology-Heart and Circulatory Physiology, 288: H1278-H1289, 2005
  74. Radisic M , Park H, Shin H, Consi T, Schoen FJ, Freed LE, Vunjak-Novakovic G: “Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds” Proceedings of the National Academy of Sciences of the United States of America, 101:18129-18134, Dec 28, 2004 (Cover article)
  75. Radisic M , Yang L, Boublik J, Langer R, Freed LE, Vunjak-Novakovic G: “Medium perfusion enables cultivation of compact and contractile cardiac tissue” American Journal of Physiology-Heart and Circulatory Physiology-Heart and Circulatory Physiology 286: H507-516, 2004
  76. Radisic M , Euloth M, Yang L, Langer R, Freed LE, Vunjak-Novakovic G: “High density seeding of myocyte cells for cardiac tissue engineering” Biotechnology and Bioengineering 82: 403-414, 2003
  77. Rodic M, (maiden name) and Hrymak AN: “The modified disc retraction method for measurement of interfacial tension in polymer melts” Rheologica Acta, 40:339-349, 2001

 

Submitted:

78. Conant G, Ahadian S, Zhao Y, Radisic M: “Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires”, Scientific Reports, submitted      

Communications (in revision)

79. Montgomery M, Ahadian S, Lo Rito M, Reis LA, Davenport-Huyer L, Akbari S, Vanderlaan R, Pahnke A, Caldarone CA, Radisic M: “Flexible Shape-memory Scaffold for Minimally Invasive Delivery of Functional Tissues”, Nature Materials, in revision

80. Korolj A, Laschinger C, James C, Hu E, Willette R, Smith N, Ahadian A, Radisic M, Zhang B: “ Biomimetic 3D platform induces nephrin upregulation in differentiating podocytes in vitro “, Lab-on-a-Chip, in revision